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Table 2 Caffeine citrate dosing regimens and caffeine serum concentrations during TDM

From: Incorporating pharmacodynamic considerations into caffeine therapeutic drug monitoring in preterm neonates

Dosing regimens Number of patients Caffeine serum concentration (mg/L)
40/5 mg/kg
 q12h 47 23 (18–26)***
20/5 mg/kg
 q24h 49 15 (11–17)
 q12h 8 17 (13–20)
5/5 mg/kg
 q24h 6 13 (8–17)
 q12h 5 22 (21–23)
  1. Data = median (interquartile range)
  2. *** p < 0.001, significant differences were observed in caffeine serum concentrations between regimen 40/5 mg/kg q12h and standard 20/5 mg/kg q24h