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Table 2 Pairwise comparisons of p- values of Helios+, Helios, CTLA-4+, IFNg+, and Treg differences, in addition to Treg subset ratios among non-vitamin D, calcitriol and cholecalciferol groups based on Kruskal-Wallis test (n = 139)

From: Low-dose oral cholecalciferol is associated with higher numbers of Helios+ and total Tregs than oral calcitriol in renal allograft recipients: an observational study

  Controls Non-vitamin D Calcitriol Cholecalciferol p value
No. of subjects 16 69 38 16  
Total Tregs*    0.108
   0.001
   <0.001
   0.016
   <0.001
   0.326
Helios+ Tregs*    0.353
   <0.001
   <0.001
   0.001
   <0.001
   0.548
Helios Tregs*    0.101
   0.062
   0.001
   0.418
   0.011
   0.173
CTLA-4+ Tregs*    0.268
   0.004
   <0.001
   0.022
   <0.001
   0.207
IFNg+ Tregs*    0.535
   0.024
   0.016
   0.095
   0.069
   0.898
Treg/CD4+ T cells    0.872
   0.002
   0.004
   0.002
   0.003
   0.861
Treg/CD8+ T cells    0.177
   0.008
   0.001
   0.062
   0.009
   0.599
Helios+/Helios Tregs    0.687
   0.018
   0.014
   0.024
   0.019
   0.941
  1. Pairwise comparisons among the four groups. p-values ≤0.008 were considered significant due to Bonferroni correction of α- values for multiple comparisons. Significant p-values are bold printed. Asterisks refer to Tregs with the marker combination of CD4+ CD25+ CD127 Foxp3+