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Table 3 CD4+ and Treg subset counts and ratios of Helios+ and total Treg cell counts in the higher-dose calcitriol group vs. cholecalciferol and non-vitamin D groups (n = 101)

From: Low-dose oral cholecalciferol is associated with higher numbers of Helios+ and total Tregs than oral calcitriol in renal allograft recipients: an observational study

  Non-vitamin D Higher-dose Calcitriol Cholecalciferol P value
No. of subjects 69 16 16  
CD4+ T cells/μl 677 (373–1043) 458 (315–879) 595 (352–1070) 0.544
Tregs/μl* 3.1 (1.6–5.3) 2.3 (1.2–4.1) 4.7 (3–8.5) 0.021
Helios+ Tregs/μl* 0.7 (0.3–1.4) 0.4 (0.2–1.6) 2.2 (1.1–3.8) 0.001
Helios Tregs/μl* 2.2 (0.9–3.9) 1.4 (0.9–3) 2.7 (1.1–4.6) 0.393
IFNg+ Tregs/μl* 0.3 (.04–0.3) 0.16 (0.06–0.4) 0.2 (0.1–0.7) 0.06
CTLA-4+ Tregs/μl* 0.4 (0.2–0.9) 0.25 (0–0.7) 1.2 (0.2–3.5) 0.018
Treg/CD4+ T cells % 0.45 (0.29–0.78) 0.44 (0.25–0.95) 0.84 (0.53–1.4) 0.006
Treg/ CD8+ T cells % 0.84 (0.37–1.5) 0.57 (0.27–1.2) 1.4 (0.9–1.8) 0.058
Helios+/ Helios Tregs 0.38 (0.27–0.61) 0.28 (0.19–0.97) 0.65 (0.38–1.4) 0.048
  1. Tregs denoted with asterisks have the marker combination CD4+ CD25+ CD127 Foxp3+