Low-dose oral cholecalciferol is associated with higher numbers of Helios+ and total Tregs than oral calcitriol in renal allograft recipients: an observational study

Table 4 Pairwise comparisons of p-values of Helios⁺, CTLA-4, and Treg differences, in addition to Treg subset ratios among non-vitamin D, calcitriol and cholecalciferol groups based on Kruskal-Wallis test (n = 101)

	Non-vitamin D	Higher-dose Calcitriol	Cholecalciferol	P value
No. of subjects	69	16	16
Total Tregs*	√	√		0.349
		√	√	0.009
	√		√	0.016
Helios⁺ Tregs*	√	√		0.553
		√	√	0.002
	√		√	0.001
CTLA-4⁺ Tregs*	√	√		0.152
		√	√	0.005
	√		√	0.034
Treg/CD4⁺ T cells %	√	√		0.951
		√	√	0.012
	√		√	0.002
Helios⁺/ Helios⁻ Tregs	√	√		0.507
		√	√	0.024
	√		√	0.027

P values ≤ 0.016 were considered significant due to Bonferroni correction of α-values for multiple comparisons. Significant p-values are bold printed. Asterisks refer to Tregs with the marker combination CD4⁺ CD25⁺ CD127⁻ Foxp3⁺

ISSN: 2050-6511