From: “Ecstasy” toxicity to adolescent rats following an acute low binge dose
Parameter | Control | MDMA |
---|---|---|
Hippocampus | ||
GSHt (nmol/mg protein) | 21.17 ± 1.22 | 22.87 ± 3.46 |
GSH/GSSG ratio | 50.30 ± 12.72 | 50.26 ± 19.37 |
GSSG (nmol/mg protein) | 0.42 ± 0.09 | 0.41 ± 0.18 |
GSH (nmol/mg protein) | 20.33 ± 1.37 | 22.05 ± 3.72 |
Quinoprotein (OD/mg protein) | 6.01 ± 0.78 | 6.09 ± 0.71 |
Protein carbonylation (% of control) | 100.00 ± 28.69 | 88.01 ± 12.51 |
Frontal cortex | ||
GSHt (nmol/mg protein) | 18.60 ± 1.78 | 17.93 ± 1.70 |
GSH/GSSG ratio | 61.44 ± 10.67 | 68.60 ± 18.71 |
GSSG (nmol/mg protein) | 0.30 ± 0.05 | 0.27 ± 0.07 |
GSH (nmol/mg protein) | 18.00 ± 1.77 | 17.39 ± 1.67 |
Quinoprotein (OD/mg protein) | 5.54 ± 0.70 | 5.73 ± 0.50 |
Protein carbonylation (% of control) | 100.00 ± 11.80 | 101.15 ± 10.18 |
Striatum | ||
GSHt (nmol/mg protein) | 20.70 ± 6.14 | 20.49 ± 4.68 |
GSH/GSSG ratio | 47.49 ± 16.60 | 56.76 ± 14.98 |
GSSG (nmol/mg protein) | 0.45 ± 0.22 | 0.35 ± 0.04 |
GSH (nmol/mg protein) | 19.79 ± 5.88 | 19.78 ± 4.69 |
Quinoprotein (OD/mg protein) | 5.76 ± 0.20 | 5.78 ± 0.15 |
Protein carbonylation (% of control) | 100.00 ± 53.98 | 108.84 ± 45.81 |
Cerebellum | ||
GSHt (nmol/mg protein) | 13.32 ± 0.69 | 12.34 ± 2.80 |
GSH/GSSG ratio | 25.20 ± 6.52 | 28.77 ± 12.21 |
GSSG (nmol/mg protein) | 0.51 ± 0.12 | 0.47 ± 0.21 |
GSH (nmol/mg protein) | 12.29 ± 0.80 | 11.40 ± 2.67 |
Quinoprotein (OD/mg protein) | 5.93 ± 0.42 | 5.95 ± 0.29 |
Protein carbonylation (% of control) | 100.00 ± 27.94 | 95.43 ± 19.88 |