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Table 5 Effect of MDMA administration in caspase-3, -9 and -8 activities in the three peripheral organs

From: “Ecstasy” toxicity to adolescent rats following an acute low binge dose

Parameter (FU/μg protein) Control MDMA
Heart
 Caspase-3 0.44 ± 0.05 0.42 ± 0.06
 Caspase-9 0.09 ± 0.02 0.11 ± 0.05
 Caspase-8 0.48 ± 0.08 0.47 ± 0.11
Kidneys
 Caspase-3 0.59 ± 0.08 0.56 ± 0.06
 Caspase-9 0.90 ± 0.18 0.79 ± 0.11
 Caspase-8 0.66 ± 0.09 0.62 ± 0.07
Liver
 Caspase-3 1.19 ± 0.31 1.12 ± 0.31
 Caspase-9 0.90 ± 0.07 0.86 ± 0.13
 Caspase-8 1.00 ± 0.06 0.93 ± 0.20*
  1. Caspase-3, -8 and -9 activities in the heart, kidneys and liver of adolescent rats that received either saline or MDMA. Results of caspase-3, -8 and -9 activities, in fluorescent units per μg of protein (FU/μg protein), are presented as mean ± standard deviation, and were obtained from seven animals in each group. Statistical comparisons were made using the t-test for the caspase-3 activity in the liver, heart and kidneys and caspase-8 and -9 activities in the heart and kidneys, and the Mann-Whitney Rank Sum test for the caspase-8 and -9 activities in the liver (*p <0.05 treatment vs. control)