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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Functional and molecular evidence for heteromeric association of P2Y1 receptor with P2Y2 and P2Y4 receptors in mouse granulocytes

Fig. 5

Heterologous desensitization between ADP and UTP also occurs in hematopoietic progenitor cells. Cells were loaded with the Ca2+ indicator fluo-4, and intensity was measured with confocal microscopy (LSM 510 META). Scale bar = 20 μM. The images are a pseudocolored representation in reference to the fluorescence intensity scale (0 = black, 255 = white). a Images in two Z planes showed cell preparations before agonist addition (basal) and after stimulation (max) with 1 mM of ADP and UTP. b Records of fluorescence intensity as a function of time corresponded to images of hematopoietic and stromal cells in a, and represented responses of four independent experiments

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