Fig. 1
From: Virtual screening and experimental validation of novel histone deacetylase inhibitors
Pharmacophore MODEL_006 and its molecular alignment derived from the representative compounds. a Molecular alignment of 7 representative compounds. b Pharmacophore model (length unit: angstrom): three hydrophobes (HY5, HY6 and HY7), two hydrogen bond (HB) acceptors (AA3 and AA4), and two HB donors (DA1 and DA2). Cyan spheres represent hydrophobes; green spheres indicate HB acceptors; and magenta spheres indicate HB donors. Note that the pharmacophore AA_4 and DA_2 were overlapped each other