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Table 8 Comparison of the IC50 values of SAHA, ZINC12555961, ZINC02639234 and ZINC09715944 against the HepG2, L02, MDA-MB-231 and MCF-10A cell lines

From: Virtual screening and experimental validation of novel histone deacetylase inhibitors

Chemicals

IC50(μM)

HepG2

L02

MDA-MB-231

MCF-10A

SAHA

166 ± 9

85 ± 2

178 ± 13

59 ± 10

ZINC12555961

87 ± 10

85 ± 15

57 ± 7

142 ± 17

ZINC02639234

>200

>200

>200

>200

ZINC09715944

157 ± 12

65 ± 3

>200

47 ± 7

  1. Data are expressed as the mean ± SD from at least three independent experiments