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Table 8 Comparison of the IC50 values of SAHA, ZINC12555961, ZINC02639234 and ZINC09715944 against the HepG2, L02, MDA-MB-231 and MCF-10A cell lines

From: Virtual screening and experimental validation of novel histone deacetylase inhibitors

Chemicals IC50(μM)
HepG2 L02 MDA-MB-231 MCF-10A
SAHA 166 ± 9 85 ± 2 178 ± 13 59 ± 10
ZINC12555961 87 ± 10 85 ± 15 57 ± 7 142 ± 17
ZINC02639234 >200 >200 >200 >200
ZINC09715944 157 ± 12 65 ± 3 >200 47 ± 7
  1. Data are expressed as the mean ± SD from at least three independent experiments