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Table 2 Average tissue-to-plasma partition coefficients in pregnant or lactating rats after i.v. injection (2.7 and 5.5 mg/kg) plus i.v. infusion (0.17 and 0.34 mg/h/kg) for 100 and 200 ng/mL of Css,plasma, respectively

From: Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats

Tissue Tissue to plasma partition coefficient, KP (%)
100 ng/mL (n = 6) 200 ng/mL (n = 5)
Placenta 59.0 ± 7.9 44.6 ± 9.4
Amniotic fluid 1.7 ± 0.7 1.3 ± 0.9
Fetus 14.9 ± 1.3 17.0 ± 9.2
Milk 10.4 ± 6.0 15.2 ± 6.1