From: Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats
Tissue | Tissue to plasma partition coefficient, KP (%) | |
---|---|---|
100 ng/mL (n = 6) | 200 ng/mL (n = 5) | |
Placenta | 59.0 ± 7.9 | 44.6 ± 9.4 |
Amniotic fluid | 1.7 ± 0.7 | 1.3 ± 0.9 |
Fetus | 14.9 ± 1.3 | 17.0 ± 9.2 |
Milk | 10.4 ± 6.0 | 15.2 ± 6.1 |