Fig. 4

Locomotor and food behavioral control studies of l-THP. l-THP 3-5 mg/kg displayed no sedative effects on locomotor activity or responding for food, all data is presented as mean + S.E.M. a In locomotor testing, rats were acclimated to locomotor chambers. Rats were then pretreated with saline or l-THP 30 min before placement into locomotor chambers and treated with saline 5 min before placement into locomotor chambers. Rats were trained under this protocol for six consecutive days. No significant difference was found in locomotor activity between saline and l-THP between the doses of 3–5 mg/kg, n = 8 per group. b In food testing, rats were trained to respond in operant chambers under an FR 10, 20-s time out schedule for sucrose pellets. Sessions lasted 1-h, once rats received the maximum number of pellets (40 pellets) for three consecutive sessions they were tested with pretreatment of l-THP in escalating doses; at least five sessions of saline treatment were given between test doses. l-THP at 7 mg/kg and 9 mg/kg significantly reduced the responding rate for sucrose pellets within the 1-h session, one-way ANOVA, ** p < 0.01, n = 10 per group