Table 3 Effects of plumbagin on (A) blood chemistry and (B) hematological parameters in serum of rats after daily oral administration at 25 mg/kg body weight for 28 days (3 males and 3 females for each group). Data are presented as median (interquartile range)
From: Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin
| Parameter | Control | Plumbagin 25 mg/kg body weight |
|---|---|---|
| (A) | ||
| Glucose (mg/dL) | 248 (80) | 230 (59) |
| BUN (mg/dL) | 20.5 (6.5) | 22.0 (7.5) |
| Creatinine (mg/dL) | 0.50 (0.00) | 0.50 (0.00) |
| Cholesterol (mg/dL) | 68 (3) | 73 (6) |
| Triglyceride (mg/dL) | 106 (13) | 110 (9) |
| AST (U/L) | 100 (17) | 101 (15) |
| ALT (U/L) | 27 (10) | 30 (11) |
| (B) | ||
| RBC (×106/μL) | 8.27 (0.50) | 8.16 (0.72) |
| Hemoglobin (g/dL) | 14.9 (0.7) | 14.4 (1.2) |
| Hematocrit (%) | 47.9 (3.0) | 47.8 (2.6) |
| WBC (×103/μL) | 9.10 (0.80) | 9.40 (0.65) |
| Neutrophils (×103/μL) | 1.92 (0.11) | 2.20 (0.63) |
| Eosinophils (×103/μL) | 0.50 (1.00) | 0.00 (1.00) |
| Lymphocytes (×103/μL) | 7.41 (0.28) | 7.59 (0.31) |
| Monocytes (×103/μL) | 0.00 (1.00) | 0.00 (1.00) |
| Platelets count (×103/μL) | 870.00 (191.25) | 885.50 (73.75) |
| Blood morphology | Normal | Normal |