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Table 3 Effects of plumbagin on (A) blood chemistry and (B) hematological parameters in serum of rats after daily oral administration at 25 mg/kg body weight for 28 days (3 males and 3 females for each group). Data are presented as median (interquartile range)

From: Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin

Parameter Control Plumbagin 25 mg/kg body weight
(A)
 Glucose (mg/dL) 248 (80) 230 (59)
 BUN (mg/dL) 20.5 (6.5) 22.0 (7.5)
 Creatinine (mg/dL) 0.50 (0.00) 0.50 (0.00)
 Cholesterol (mg/dL) 68 (3) 73 (6)
 Triglyceride (mg/dL) 106 (13) 110 (9)
 AST (U/L) 100 (17) 101 (15)
 ALT (U/L) 27 (10) 30 (11)
(B)
 RBC (×106/μL) 8.27 (0.50) 8.16 (0.72)
 Hemoglobin (g/dL) 14.9 (0.7) 14.4 (1.2)
 Hematocrit (%) 47.9 (3.0) 47.8 (2.6)
 WBC (×103/μL) 9.10 (0.80) 9.40 (0.65)
 Neutrophils (×103/μL) 1.92 (0.11) 2.20 (0.63)
 Eosinophils (×103/μL) 0.50 (1.00) 0.00 (1.00)
 Lymphocytes (×103/μL) 7.41 (0.28) 7.59 (0.31)
 Monocytes (×103/μL) 0.00 (1.00) 0.00 (1.00)
 Platelets count (×103/μL) 870.00 (191.25) 885.50 (73.75)
 Blood morphology Normal Normal