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Table 4 The pharmacokinetic parameters of plumbagin after oral administration of 100 mg/kg body weight of plumbagin to healthy male Wistar rats [median (interquartile range), n = 4]

From: Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin

Parameter Plumbagin
t1/2 (h) 9.63 (3.04)
tmax (h) 5.0 (0.0)
Cmax (μg/mL) 0.46 (0.15)
AUC0-48h (μg∙h/mL) 6.51 (1.16)
AUC0−∞ (μg∙h/mL) 6.71 (1.41)
MRT (h) 12.88 (2.49)
Vd/F (L/mg dose/kg body weight) 0.0022 (0.00)
CL/F (L/h/mg dose/kg body weight) 0.15 (0.3)