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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice

Fig. 2

a-cFrontal cortical DA, 5HT and NE levels (mean ± sem) for each sex, percent of WT Cu0 control mean. There were significant main effect of MTKO increasing frontal cortical DA (p < 0.05) 5HT (p < 0.005) levels relative to WT mice. With DA levels there was also a significant sex effect with males having higher levels than females (p < 0.05). Number of rats/condition: Wildtype Cu0 males = 16, Wildtype Cu0 females = 13; Wildtype Cu10 males = 23; Wildtype Cu10 females = 13; MTKO Cu0 males = 11; MTKO Cu0 females = 19; MTKO Cu10 males = 10; MTKO Cu10 females = 15. d-e Frontal cortical DA and 5HT turnover (mean ± sem) for each sex, percent of WT Cu0 control mean. MTKO caused a significant (p < 0.05) increase in DA turnover relative to WT mice. In contrast the MTKO mice had significantly (p < 0.0005) lower 5HT turnover than wildtype controls. Males had significantly (p < 0.01) lower DA turnover in the frontal cortex than females

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