Fig. 6

a-c Midbrain DA (mean ± sem) for each sex, percent of WT Cu0 control mean. With 5HT there was a significant (p < 0.0005) main effect of genotype with higher levels in the MTKO vs. WT mice. Number of rats/condition: Wildtype Cu0 males = 16, Wildtype Cu0 females = 13; Wildtype Cu10 males = 23; Wildtype Cu10 females = 13; MTKO Cu0 males = 11; MTKO Cu0 females = 19; MTKO Cu10 males = 10; MTKO Cu10 females = 15. d-e Midbrain DA and 5HT turnover (mean ± sem) for each sex, percent of WT Cu0 control mean. DA turnover was significantly (p < 0.001) increased in MTKO vs. WT mice. With 5HT turnover, there was a significant (p < 0.05) decrease with copper treatment in WT males, but a significant(p < 0.05) increase in MTKO females