Fig. 7

a-c Brainstem DA, 5HT and NE (mean ± sem) for each sex, percent of WT Cu0 control mean. There was a significant main effect of genotype with DA levels (p < 0.05) with MTKO causing an overall increase. A robust effect was seen with significantly (p < 0.0005) higher 5HT levels in male MTKO mice relative to male WT. NE levels in MTKO mice were significantly (p < 0.005) higher than WT regardless of sex. Number of rats/condition: Wildtype Cu0 males = 16, Wildtype Cu0 females = 13; Wildtype Cu10 males = 23; Wildtype Cu10 females = 13; MTKO Cu0 males = 11; MTKO Cu0 females = 19; MTKO Cu10 males = 10; MTKO Cu10 females = 15. d-e Brainstem DA and 5HT turnover (mean ± sem) for each sex, percent of WT Cu0 control mean. With DA turnover there was a significant (p < 0.05) main effect of genotype with MTKO mice having higher turnover than WT mice. With 5HT turnover there was a significant (p < 0.05) decrease caused by Cu10 in female WT mice, but a significant (p < 0.005) increase in female MTKO mice. There was a significant (p < 0.001) sex effect with males having lower turnover than females