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Table 1 Summary of copper, genotype and sex effects on dopamine, serotonin and norepinephrine

From: Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice

  Copper MTKO Sex
Frontal Cortex
 DA Level   −11 % MTKO < WT +10 % Males > Females
 DA Turnover   +17 % MTKO > WT −13 % Males < Females
 5HT Level   +10 % MTKO > WT  
 5HT Turnover   −17 % MTKO < WT  
 NE Level    
Posterior Cortex
 DA Level    
 5HT Level   +34 % MTKO > WT  
 5HT Turnover    −6 % Males < Females
 NE Level    
Hippocampus
 DA Level +56 % Cu > Con Females +41 % MTKO > WT Females  
 DA Turnover −31 % Cu < Con Females   
 5HT Level   +8 % MTKO > WT −7 % Males < Females
 5HT Turnover −13 % Cu < Con in WT   
 NE Level   +11 % MTKO > WT +5 % Males > Females
Striatum
 DA Level    
 DA Turnover −14 % Cu < Con   
 5HT Level   +13 % MTKO > WT  
 5HT Turnover    
 NE Level    
Midbrain
 DA Level    
 DA Turnover   +10%MTKO > WT  
 5HT Level   +17 % MTKO > WT  
 5HT Turnover −7 % Cu < Con WT Males   
+10 % Cu > Con MTKO Females
 NE Level    
Brainstem
 DA Level   +17 % MTKO > WT  
 DA Turnover   +13 % MTKO > WT  
 5HT Level   +35 % MTKO > WT Males  
 5HT Turnover −12 % Cu < Con female WT   
+17 % Cu > Con Female MTKO
 NE Level   +8 % MTKO > WT