Table 1 Summary of copper, genotype and sex effects on dopamine, serotonin and norepinephrine
Copper | MTKO | Sex | |
|---|---|---|---|
Frontal Cortex | |||
DA Level | −11 % MTKO < WT | +10 % Males > Females | |
DA Turnover | +17 % MTKO > WT | −13 % Males < Females | |
5HT Level | +10 % MTKO > WT | ||
5HT Turnover | −17 % MTKO < WT | ||
NE Level | |||
Posterior Cortex | |||
DA Level | |||
5HT Level | +34 % MTKO > WT | ||
5HT Turnover | −6 % Males < Females | ||
NE Level | |||
Hippocampus | |||
DA Level | +56 % Cu > Con Females | +41 % MTKO > WT Females | |
DA Turnover | −31 % Cu < Con Females | ||
5HT Level | +8 % MTKO > WT | −7 % Males < Females | |
5HT Turnover | −13 % Cu < Con in WT | ||
NE Level | +11 % MTKO > WT | +5 % Males > Females | |
Striatum | |||
DA Level | |||
DA Turnover | −14 % Cu < Con | ||
5HT Level | +13 % MTKO > WT | ||
5HT Turnover | |||
NE Level | |||
Midbrain | |||
DA Level | |||
DA Turnover | +10%MTKO > WT | ||
5HT Level | +17 % MTKO > WT | ||
5HT Turnover | −7 % Cu < Con WT Males | ||
+10 % Cu > Con MTKO Females | |||
NE Level | |||
Brainstem | |||
DA Level | +17 % MTKO > WT | ||
DA Turnover | +13 % MTKO > WT | ||
5HT Level | +35 % MTKO > WT Males | ||
5HT Turnover | −12 % Cu < Con female WT | ||
+17 % Cu > Con Female MTKO | |||
NE Level | +8 % MTKO > WT | ||