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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapses

Fig. 1

Dentate Gyrus –Perforant Pathway (DG-PP) synapses and CA3-Mossy Fiber Pathway (CA3-MF) Synapses. (a) Control DG-PP synapse, (b) Pb2+ DG-PP synapse, (c) Control CA3-MF synapse, and (d) Pb2+ CA3-MF synapse. There are more docked vesicles in presynaptic terminals of control rats than there are in Pb2+ exposed rats. Docked vesicles are those that are physically contacting the presynaptic active zone (PAZ). There is also a reduction in recycling pool vesicles in Pb2+ exposed groups. No overall reduction in total vesicle number was found. The postsynaptic density was markedly smaller in the CA3-MF terminals of Pb2+ exposure groups. Scale bar = 500 nm

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