Skip to main content

Table 4 Effects of Manganese (Mn) exposure on AChE activity in different experimental protocols

From: “Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

Model

Tissue

Administration route and dose

Effect on AChE activity

Reference

Adult rats

Whole Brain

Intraperitoneal-acute (10–15 mg/kg) and chronic (mg/kg)

Increase

[100]

Adult rats

Cerebellum

Oral via by drinking water, 30 days (20 mg/ml)

Increase

[189]

Rats from 21–74 days

Brain

Oral via by food, for 53 days, chronic exposure (500 mg/kg)

Increase

[94]

Adult mice

Hypothalamus, pons, cerebellum, striatum, medulla, cerebral cortex and hippocampus.

Chronic treatment by oral via from conception to 60 days old

No alterations

[98]

0-adult rats

Cerebellum and striatum

Oral via by drinking water, 60 days (20 mg/ml)

Increase

[97]

Adult rats

Brain

Intraperitoneal, 7 days (50 mg/kg)

Increase

[99]

Adult rats

Whole Brain

Intraperitoneal-(25 mg/kg) in 4 and 8 doses

Decrease

[84]