Pharmacokinetic and pharmacodynamic characterization of a novel formulation containing co-formulated interferons alpha-2b and gamma in healthy male volunteers

Table 1 Model description of the seven compartmental models used and estimated parameters

Model	Description	Parameters
I	Mono-compartmental with zero order absorption and bioavailability	Tk0, F, V, k
II	Mono-compartmental with first order absorption and bioavailability	ka, F, V, k
III	Bi-compartmental with first order absorption and bioavailability	ka, F, V, k, k₁₂, k₂₁
IV	Mono-compartmental with simultaneous zero order and first order absorption	Tk0, ka, F, V, k
V	Mono-compartmental with consecutive zero order and first order absorption. One bioavailability value	Tk0, ka, F, V, k
VI	Mono-compartmental with two simultaneous first order absorptions	ka1, F, ka2, V, k
VII	Mono-compartmental with consecutive zero order and first order absorption. One bioavailability value for each absorption component	Tk0, ka, F1, F2, V, k

Tk0 duration of zero order absorption, F bioavailability associated to absorption processes, V volume of distribution of central compartment, ka rate constant of first order absorption, k first order elimination rate constant, k₁₂ and k₂₁: first order inter-compartmental rate constants

ISSN: 2050-6511