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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: 5-aminolevulinic acid combined with ferrous ion reduces adiposity and improves glucose tolerance in diet-induced obese mice via enhancing mitochondrial function

Fig. 1

Heme synthesis pathway in animal cells. ALA is synthesized by the condensation of glycine and succinyl CoA via mitochondrial ALA synthase. The polymerization of 8 molecules of ALA in several subsequent steps produces protoporphyrin IX (PpIX). Heme is synthesized by the insertion of a ferrous ion into PpIX, and incorporated into proteins to produce heme-proteins such as hemoglobin, cytochrome, and P450

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