|
Risk category
|
Cardiovascular risk factorsa
|
Randomization criteria
|
|---|
|
LDL-cholesterol (mg/dL)
|
Averaged sitting SBP (mmHg)
|
|---|
|
Low risk
|
0 risk factors
|
≥160 and ≤ 250
|
≥140 and < 180
|
|
Moderate risk
|
1+ risk factors and 10 year risk < 10%
|
≥160 and ≤ 250
|
|
Moderate high risk
|
1+ risk factors and 10-year risk from 10% to 20%
|
≥130 and ≤ 250
|
|
High risk
|
CHDb and CHD risk equivalentc
|
≥100 and ≤ 250
|
-
aRisk factors: include cigarette smoking, hypertension (BP ≥ 140/90 mm Hg or on antihypertensive medication), low HDL cholesterol (<40 mg/dL), family history of premature CHD (CHD in male first-degree relative < 55 years of age; CHD in female first-degree relative < 65 years of age), and age (men ≥ 45 years; women ≥ 55 years)
-
bCHD (coronary heart disease) includes history of myocardial infarction, unstable angina, stable angina, coronary artery procedures (angioplasty or bypass surgery), or evidence of clinically significant myocardial ischemia
-
cCHD (coronary heart disease) risk equivalents include clinical manifestations of noncoronary forms of atherosclerotic disease (peripheral arterial disease, abdominal aortic aneurysm, and carotid artery disease [transient ischemic attacks or stroke of carotid origin or > 50% obstruction of a carotid artery]), diabetes, and 2+ risk factors with 10-year risk for hard CHD > 20%
