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Table 4 Response rate and control rate of sitting systolic blood pressure, and goal attainment rate of low-density lipoprotein cholesterol by each treatment. (Analysis of per-protocol set)

From: The efficacy and safety of co-administration of fimasartan and rosuvastatin to patients with hypertension and dyslipidemia

 

Summary of each treatment

FMS/RSV vs FMS

FMS/RSV vs RSV

 

FMS/RSV

FMS

RSV

Difference(SE)

P-valued

Difference(SE)

P-valued

 

N = 35

N = 36)

N = 37

(95% C.I.)

 

(95% C.I.)

 

siSBP

       

 Response ratea, n (%)

26 (74.29)

23 (63.89)

15 (40.54)

10.40 (10.89)

 

33.75 (10.94)

 

  95% CI

(59.81, 88.77)

(48.20, 79.58)

(24.72, 56.36)

(−10.95, 31.75)

0.390

(12.30, 55.19)

0.010

 Control rateb, n (%)

26 (74.29)

23 (63.89)

13 (35.14)

10.40 (10.89)

 

39.15 (10.78)

 

  95% CI

(59.81, 88.77)

(48.20, 79.58)

(19.75, 50.52)

(−10.95, 31.75)

0.358

(18.03, 60.28)

0.003

LDL-C

       

 Goal attainment ratec, n (%)

33 (94.29)

7 (19.44)

34 (91.89)

74.84 (7.67)

 

2.39 (5.96)

 

  95% CI

(86.60, 100.00)

(6.52, 32.37)

(83.10, 100.00)

(59.80, 89.88)

<0.001

(−21.13, 25.12)

0.082

  1. FMS/RSV fimasartan 120 mg/rosuvastatin 20 mg treatment, FMS fimasartan 120 mg alone treatment, RSV rosuvastatin 20 mg alone treatment, siSBP sitting systolic blood pressure, LDL-C low-density lipoprotein cholesterol, CI confidence interval, SE standard error
  2. aResponse Rate of siSBP: proportion of the subjects whose siSBP < 140 mmHg or Chang from Baseline of siSBP at Week 8 ≥ 20 mmHg
  3. bControl rate of siSBP: proportion of the subjects whose siSBP < 140 mmHg
  4. cGoal attainment rate of LDL-C: proportion of the subjects whose LDL-C < 100 mg/dL (high risk), LDL-C < 130 mg/dL (moderate high or moderate risk), LDL-C < 160 mg/dL (low risk)
  5. dComparison between combination therapy and monotherapy was analyzed by Logistic regression model adjusted for baseline values, age, and gender, smoking status