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Table 1 Liver function tests and QTc interval (pre and during posaconazole treatment)

From: A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring

  Pre-posaconazole treatment During posaconazole treatment p-value
Aspartate transaminase (median, range) 210, 64-982 units/L 109, 48-375 units/L 0.005
Alanine transferase (median, range) 223, 69-1060 units/L 121, 78-409 units/L 0.028
Alkaline phosphatase (median, range) 143, 60-323 units/L 286, 180-478 units/L <0.001
Gamma-glutamyl transpeptidase (median, range) 104, 33-341 units/L 146, 84-421 units/L 0.039
Total bilirubin (mean+/-SD) 22.38+/-10.45 mg/dL 19.57+/-3.42 mg/dL 0.124
Direct bilirubin (median, range) 16.20, 1.50-26.00 mg/dL 13.30, 9.10-16.30 mg/dL 0.217
QTc interval(median, range) 0.435, 0.350-0.490 s 0.450, 0.400-0.490 s 0.060
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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