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Table 1 Liver function tests and QTc interval (pre and during posaconazole treatment)

From: A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring

 

Pre-posaconazole treatment

During posaconazole treatment

p-value

Aspartate transaminase (median, range)

210, 64-982 units/L

109, 48-375 units/L

0.005

Alanine transferase (median, range)

223, 69-1060 units/L

121, 78-409 units/L

0.028

Alkaline phosphatase (median, range)

143, 60-323 units/L

286, 180-478 units/L

<0.001

Gamma-glutamyl transpeptidase (median, range)

104, 33-341 units/L

146, 84-421 units/L

0.039

Total bilirubin (mean+/-SD)

22.38+/-10.45 mg/dL

19.57+/-3.42 mg/dL

0.124

Direct bilirubin (median, range)

16.20, 1.50-26.00 mg/dL

13.30, 9.10-16.30 mg/dL

0.217

QTc interval(median, range)

0.435, 0.350-0.490 s

0.450, 0.400-0.490 s

0.060