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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects

Fig. 4

Similarities between carbonic anhydrase and chorismate pyruvate lyase (a) Both structures have different folds and are superimposed using the MIF similarities. b The IsoMif pose (cyan) and the FlexAID pose (salmon), RMSD of 1.62 Å. c Similarities for hydrophobic (cyan), aromatic (orange), donor (blue), acceptor (red) and negative charge (magenta). Large spheres represent probes of 1RJ6 and small ones of 1TT8

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