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Table 2 Summary of the cumulative transport results showing the mean ER values after 60 min

From: Drug-transporter mediated interactions between anthelminthic and antiretroviral drugs across the Caco-2 cell monolayers

 

Papp (106 cm/s)

Mean ER value

SD

p value

Comments

AP → BL

BL → AP

1

A

PZQ

7.6

8.6

1.14

0.17

0.5008

No significant influence on PZQ transport

B

PZQ + SQV

5.0

6.6

1.34

0.27

A

SQV

6.6

10.8

3.55

1.72

0.6796

No significant influence on SQV transport

B

SQV + PZQ

18.3

27.0

2.65

1.57

2

A

PZQ

28.1

28.6

1.03

0.19

0.0964

No significant influence on PZQ transport

B

PZQ + NVP

37.2

30.5

0.82

0.08

A

PZQ

35.0

30.3

0.87

0.17

0.4676

No significant influence on PZQ transport

B

PZQ + EFV

35.1

39.2

1.19

0.18

3

A

IVM

7.4

5.9

0.86

0.18

0.2007

No significant influence on IVM transport

B

IVM + SQV

6.4

6.3

0.99

0.16

A

SQV

6.9

21.1

3.05

0.46

0.0328

Potential for interaction; efflux transport of SQV inhibited

B

SQV + IVM

6.2

7.7

1.24

0.14

4

A

IVM

14.1

11.3

0.80

0.07

0.0094

Potential for interaction; efflux transport of IVM increased

B

IVM + NVP

4.8

8.6

1.76

0.13

A

NVP

42.7

39.5

0.91

0.12

0.6891

No significant influence on IVM transport

B

NVP + IVM

39.4

36.6

0.98

0.17

5

A

IVM

4.5

13.2

2.89

0.50

0.1822

No significant influence on IVM transport

B

IVM + LPV

6.7

9.5

1.58

0.62

A

LPV

4.8

32.1

6.72

0.54

0.0038

Potential for interaction; efflux transport of LPV inhibited

B

LPV + IVM

15.9

12.3

0.78

0.10

6

A

IVM

7.6

8.9

1.19

0.15

0.4280

No significant influence on IVM transport

B

IVM + EFV

4.7

7.3

1.67

0.69

A

EFV

16.5

10.8

0.66

0.07

0.0310

Potential for interaction; efflux transport of EFV increased

B

EFV + IVM

8.6

7.7

0.90

0.03

  1. Drug A Drug whose transport is under investigation
  2. Drug B Drug A plus the interacting drug
  3. ER Efflux ratio