| Papp (106 cm/s) | Mean ER value | SD | p value | Comments | |||
---|---|---|---|---|---|---|---|---|
AP → BL | BL → AP | |||||||
1 | A | PZQ | 7.6 | 8.6 | 1.14 | 0.17 | 0.5008 | No significant influence on PZQ transport |
B | PZQ + SQV | 5.0 | 6.6 | 1.34 | 0.27 | |||
A | SQV | 6.6 | 10.8 | 3.55 | 1.72 | 0.6796 | No significant influence on SQV transport | |
B | SQV + PZQ | 18.3 | 27.0 | 2.65 | 1.57 | |||
2 | A | PZQ | 28.1 | 28.6 | 1.03 | 0.19 | 0.0964 | No significant influence on PZQ transport |
B | PZQ + NVP | 37.2 | 30.5 | 0.82 | 0.08 | |||
A | PZQ | 35.0 | 30.3 | 0.87 | 0.17 | 0.4676 | No significant influence on PZQ transport | |
B | PZQ + EFV | 35.1 | 39.2 | 1.19 | 0.18 | |||
3 | A | IVM | 7.4 | 5.9 | 0.86 | 0.18 | 0.2007 | No significant influence on IVM transport |
B | IVM + SQV | 6.4 | 6.3 | 0.99 | 0.16 | |||
A | SQV | 6.9 | 21.1 | 3.05 | 0.46 | 0.0328 | Potential for interaction; efflux transport of SQV inhibited | |
B | SQV + IVM | 6.2 | 7.7 | 1.24 | 0.14 | |||
4 | A | IVM | 14.1 | 11.3 | 0.80 | 0.07 | 0.0094 | Potential for interaction; efflux transport of IVM increased |
B | IVM + NVP | 4.8 | 8.6 | 1.76 | 0.13 | |||
A | NVP | 42.7 | 39.5 | 0.91 | 0.12 | 0.6891 | No significant influence on IVM transport | |
B | NVP + IVM | 39.4 | 36.6 | 0.98 | 0.17 | |||
5 | A | IVM | 4.5 | 13.2 | 2.89 | 0.50 | 0.1822 | No significant influence on IVM transport |
B | IVM + LPV | 6.7 | 9.5 | 1.58 | 0.62 | |||
A | LPV | 4.8 | 32.1 | 6.72 | 0.54 | 0.0038 | Potential for interaction; efflux transport of LPV inhibited | |
B | LPV + IVM | 15.9 | 12.3 | 0.78 | 0.10 | |||
6 | A | IVM | 7.6 | 8.9 | 1.19 | 0.15 | 0.4280 | No significant influence on IVM transport |
B | IVM + EFV | 4.7 | 7.3 | 1.67 | 0.69 | |||
A | EFV | 16.5 | 10.8 | 0.66 | 0.07 | 0.0310 | Potential for interaction; efflux transport of EFV increased | |
B | EFV + IVM | 8.6 | 7.7 | 0.90 | 0.03 |