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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

Fig. 2

Comparison of contractile function in response to 60 mM KCl (a) and 10−6 M 5-hydroxytryptamine (5-HT, b) in middle cerebral artery isolated from WKY, WKY + SAL, GK, and GK + SAL rats, respectively. SAL was administrated with different dosage of 50, 100 and 200 mg/kg/day for 4 weeks in Experiment I, Experiment II, and Experiment III, respectively. Chronic administration of 50 mg/kg/day SAL had no obvious effects on contractile responsiveness to KCl (A) and 5-HT (b) in WKY or GK rats, respectively. However, chronic administration of 100 mg/kg/day SAL significantly inhibited the augmented contractile responsiveness to KCl (a) and 5-HT (b) in GK rats, whereas did not change the contractile responsiveness in WKY rats. In addition, chronic administration of 200 mg/kg/day SAL significantly inhibited the contractile responsiveness to KCl (a) and 5-HT (b) in both WKY and GK rats, respectively. WKY: control WKY rats, WKY + SAL: control WKY rats administrated with SAL, GK: diabetic GK rats, GK + SAL: GK rats administrated with SAL. Values are expressed as means ± SEM and n = 8 animals in each group. *P < 0.05 vs. WKY rats and #P < 0.05 vs. GK rats

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