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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

Fig. 3

Chronic administration of 100 mg/kg/day SAL significantly inhibited the contractile responsiveness of middle cerebral artery to cumulative superfusion of KCl (a) and 5-hydroxytryptamine (5-HT, b) in diabetic GK rats. Concentration-response relationships of middle cerebral artery were represented as the percentage of luminal diameter relative to the baseline internal diameter. WKY: control WKY rats, WKY + SAL: control WKY rats administrated with 100 mg/kg/day SAL, GK: diabetic GK rats, GK + SAL: GK rats administrated with 100 mg/kg/day SAL. Values are expressed as means ± SEM and n = 8 animals in each group. *P < 0.05 vs. WKY rats and #P < 0.05 vs. GK rats

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