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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

Fig. 4

Chronic administration of 100 mg/kg/day SAL markedly decreased whole-cell CaL current densities of cerebral VSMCs isolated from diabetic GK rats. Representative recording traces were used to show the whole-cell CaL currents (a) and the mean I-V curves were further expressed in terms of current densities (b) in WKY, WKY + SAL, GK, and GK + SAL rats. WKY: control WKY rats, WKY + SAL: control WKY rats administrated with 100 mg/kg/day SAL, GK: diabetic GK rats, GK + SAL: GK rats administrated with 100 mg/kg/day SAL. Values are means ± SEM with the number of cells recorded in parentheses. *P < 0.05 vs. WKY rats and #P < 0.05 vs. GK rats

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