Fig. 7From: Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cellsAcute application of SAL directly inhibited the CaL currents in cerebral VSMCs isolated from normal WKY rats under hyperglycemia condition. Representative traces of CaL channel current were recorded at +10 mV in cerebral VSMCs when exposed to 20 mM d-glucose and then subsequent acute application of 100 μM SAL in the presence of 20 mM d-glucose. Lastly, washing with 20 mM d-glucose could diminish the effects of SAL on CaL currents (A). Summarized data indicated the amplitudes of CaL channel current at +10 mV before and after application of 20 mM d-glucose and 100 μM SAL, respectively. Values are means ± SEM with the number of cells recorded in parentheses. *P < 0.05 vs. control condition and #P < 0.05 vs. high glucose conditionBack to article page