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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

Fig. 7

Acute application of SAL directly inhibited the CaL currents in cerebral VSMCs isolated from normal WKY rats under hyperglycemia condition. Representative traces of CaL channel current were recorded at +10 mV in cerebral VSMCs when exposed to 20 mM d-glucose and then subsequent acute application of 100 μM SAL in the presence of 20 mM d-glucose. Lastly, washing with 20 mM d-glucose could diminish the effects of SAL on CaL currents (A). Summarized data indicated the amplitudes of CaL channel current at +10 mV before and after application of 20 mM d-glucose and 100 μM SAL, respectively. Values are means ± SEM with the number of cells recorded in parentheses. *P < 0.05 vs. control condition and #P < 0.05 vs. high glucose condition

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