TY - JOUR AU - Kustiawan, Paula Mariana AU - Lirdprapamongkol, Kriengsak AU - Palaga, Tanapat AU - Puthong, Songchan AU - Phuwapraisirisan, Preecha AU - Svasti, Jisnuson AU - Chanchao, Chanpen PY - 2017 DA - 2017/05/04 TI - Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line JO - BMC Pharmacology and Toxicology SP - 32 VL - 18 IS - 1 AB - Cardol is a major bioactive constituent in the Trigona incisa propolis from Indonesia, with a strong in vitro antiproliferative activity against the SW620 colorectal adenocarcinoma cell line (IC50 of 4.51 ± 0.76 μg/mL). Cardol induced G0/G1 cell cycle arrest and apoptotic cell death. The present study was designed to reveal the mechanism of cardol’s antiproliferative effect and induction of apoptosis. SN - 2050-6511 UR - https://doi.org/10.1186/s40360-017-0139-4 DO - 10.1186/s40360-017-0139-4 ID - Kustiawan2017 ER -