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Table 4 Space clusters of temporal trends of ADE incidence rate found in 2004–2013, 2004–2008 and 2009–2013. Positive and negative percentages correspond to increasing or decreasing trends, respectively

From: A decade of adverse drug events in Portuguese hospitals: space-time clustering and spatial variation in temporal trends

Time-period a-b global trend (%)

Clusters (p < 0,05)

No. of cases in a-b (no. of municipalities)

Trends (%)

ADE rate x 10¯4 in period a

ADE rate x 10¯4 in period b

2004–2013

I

16403 (44)

14,8

65.8

204.6

(7,83%)

II

36146 (8)

3,8

184.6

253.7

 

III

12883 (38)

11.4

91.3

202.5

 

IV

13528 (40)

4.8

117.3

177.9

 

V

3841 (9)

12.4

103.4

287.5

 

VI

1126 (8)

1.4

79.8

142.1

2004–2008

VII

2997 (26)

17.1

95.8

165.1

(3,70%)

VIII

335 (2)

40.1

46.1

164.1

 

IX

5135 (8)

−2.9

122.1

115.5

 

X

2699 (3)

12.9

108.2

158

 

XI

4216 (30)

−2.2

114.7

103.2

 

XII

1157 (10)

15.9

62.5

101.4

 

XIII

584 (2)

19.6

87

150.7

2009–2013

XIV

17598 (15)

4.5

190.7

226.8

(11.20%)

XV

12837 (44)

19.5

103.4

204.6

 

XVI

7651 (62)

5.9

127.5

169.8

 

XVII

1692 (10)

21.6

109.4

266.5

  1. Values in bold identified areas where trends were higher than global trends (for each a-b period)