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Table 4 Space clusters of temporal trends of ADE incidence rate found in 2004–2013, 2004–2008 and 2009–2013. Positive and negative percentages correspond to increasing or decreasing trends, respectively

From: A decade of adverse drug events in Portuguese hospitals: space-time clustering and spatial variation in temporal trends

Time-period a-b global trend (%) Clusters (p < 0,05) No. of cases in a-b (no. of municipalities) Trends (%) ADE rate x 10¯4 in period a ADE rate x 10¯4 in period b
2004–2013 I 16403 (44) 14,8 65.8 204.6
(7,83%) II 36146 (8) 3,8 184.6 253.7
  III 12883 (38) 11.4 91.3 202.5
  IV 13528 (40) 4.8 117.3 177.9
  V 3841 (9) 12.4 103.4 287.5
  VI 1126 (8) 1.4 79.8 142.1
2004–2008 VII 2997 (26) 17.1 95.8 165.1
(3,70%) VIII 335 (2) 40.1 46.1 164.1
  IX 5135 (8) −2.9 122.1 115.5
  X 2699 (3) 12.9 108.2 158
  XI 4216 (30) −2.2 114.7 103.2
  XII 1157 (10) 15.9 62.5 101.4
  XIII 584 (2) 19.6 87 150.7
2009–2013 XIV 17598 (15) 4.5 190.7 226.8
(11.20%) XV 12837 (44) 19.5 103.4 204.6
  XVI 7651 (62) 5.9 127.5 169.8
  XVII 1692 (10) 21.6 109.4 266.5
  1. Values in bold identified areas where trends were higher than global trends (for each a-b period)