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Table 3 Cox proportional hazards regression models

From: Psychotropic drug use and mortality in old people with dementia: investigating sex differences

 

Model 1

 

Model 2

 

Interaction Term

 

HR

95% CI

HR

95% CI

 

Antipsychotics (2 year mortality)

    

sex*antipsychotics

All participants

1.16

0.94–1.43

0.91

0.73–1.14

p = 0.962

Male participants

1.24

0.82–1.87

0.79

0.51–1.24

 

Female participants

1.15

0.90–1.46

0.90

0.70–1.15

 

Antidepressants (2 year mortality)

    

sex*antidepressants

All participants

1.01

0.84–1.21

0.96

0.78–1.17

p = 0.047

Male participants

0.96

0.67–1.37

0.61*

0.40–0.92

 

Female participants

1.03

0.84–1.28

1.09

0.87–1.38

 

Benzodiazepines (first-year mortality)

    

sex*benzodiazepines

All participants

1.38*

1.08–1.77

1.13

0.86–1.47

p = 0.029

Male participants

2.07*

1.29–3.32

1.37

0.77–2.45

 

Female participants

1.21

0.91–1.62

0.96

0.71–1.31

 

Benzodiazepines (second-year mortality)

    

sex*benzodiazepines

All participants

0.95

0.73–1.24

0.72*

0.54–0.96

p = 0.964

Male participants

0.90

0.51–1.59

0.81

0.45–1.45

 

Female participants

0.98

0.72–1.33

0.73

0.53–1.02

 
  1. Notes: Analyses of antipsychotics and benzodiazepines include related drugs, as described in methods. Hazard ratios marked with * are statistically significant (p < 0.05). HR Hazard ratio. CI Confidence interval. Model 1 shows the unadjusted, univariate associations between drug use and mortality. Model 2 includes all available confounders, selected through the process described in the statistics section. Interaction Term shows the p-values for the respective interaction terms applied to Model 2