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Table 3 Cox proportional hazards regression models

From: Psychotropic drug use and mortality in old people with dementia: investigating sex differences

  Model 1   Model 2   Interaction Term
  HR 95% CI HR 95% CI  
Antipsychotics (2 year mortality)      sex*antipsychotics
All participants 1.16 0.94–1.43 0.91 0.73–1.14 p = 0.962
Male participants 1.24 0.82–1.87 0.79 0.51–1.24  
Female participants 1.15 0.90–1.46 0.90 0.70–1.15  
Antidepressants (2 year mortality)      sex*antidepressants
All participants 1.01 0.84–1.21 0.96 0.78–1.17 p = 0.047
Male participants 0.96 0.67–1.37 0.61* 0.40–0.92  
Female participants 1.03 0.84–1.28 1.09 0.87–1.38  
Benzodiazepines (first-year mortality)      sex*benzodiazepines
All participants 1.38* 1.08–1.77 1.13 0.86–1.47 p = 0.029
Male participants 2.07* 1.29–3.32 1.37 0.77–2.45  
Female participants 1.21 0.91–1.62 0.96 0.71–1.31  
Benzodiazepines (second-year mortality)      sex*benzodiazepines
All participants 0.95 0.73–1.24 0.72* 0.54–0.96 p = 0.964
Male participants 0.90 0.51–1.59 0.81 0.45–1.45  
Female participants 0.98 0.72–1.33 0.73 0.53–1.02  
  1. Notes: Analyses of antipsychotics and benzodiazepines include related drugs, as described in methods. Hazard ratios marked with * are statistically significant (p < 0.05). HR Hazard ratio. CI Confidence interval. Model 1 shows the unadjusted, univariate associations between drug use and mortality. Model 2 includes all available confounders, selected through the process described in the statistics section. Interaction Term shows the p-values for the respective interaction terms applied to Model 2