Fig. 4

Repeated injections with E2HSA ameliorated insulin and glucagon secretion and β-cell function in KKAy mice. a Fasting blood insulin levels after treatment for 2 weeks, b Fasting blood glucagon levels after treatment for 7 weeks, c Glucose infusion rate (GIR). All the data are expressed as mean ± SE, n = 13 for A, 5–8 for B, and 3–5 for C. *** p < 0.001, ** p < 0.01, * p <0.05 vs. Con