Metformin is not associated with lactic acidosis in patients with diabetes undergoing coronary artery bypass graft surgery: a case control study

Table 3 Peri- operative laboratory measurements

	Group I DM + Meformin n = 41 (32%)	Group II DM - Metformin n = 86 (68%)	P-value
Serum glucose
^aFasting blood sugar (mmol/l) ± SD	10.0 ± 1.3	8.9 ± 2.1	0.001
Cardiac enzymes
^bPeak CK (U/l) ± SD	1128.5 ± 1065.1	1062.6 ± 772.8	0.693
^bPeak CK-MB (U/l) ± SD	86.4 ± 126.9	82.3 ± 66.9	0.809
^bPeak troponin I (ug/l) ± SD	2.1 ± 3.1	3.3 ± 4.8	0.185
Kidney
^bPeak creatinine (mmol/l) ± SD	109.7 ± 25.9	119.8 ± 37.2	0.122
^cAcute kidney injury	7 (17.1%)	17 (19.8%)	0.717
Liver
^bPeak total bilirubin (mmol/l) ± SD	17.6 ± 15.5	21.1 ± 15.7	0.244
^bPeak ALP (U/l) ± SD	119.7 ± 57.9	135.9 ± 92.7	0.307
^bPeak ALT (U/l) ± SD	71.0 ± 85.1	124.6 ± 251.3	0.079
^bPeak AST (U/l) ± SD	88.0 ± 108.1	134.7 ± 278.6	0.303
^bPeak GGT (U/l) ± SD	99.0 ± 90.8	107.9 ± 120.7	0.677
Other laboratory measures
^bPeak LDH (U/l) ± SD	414.0 ± 159.8	543.7 ± 337.2	0.021
^bPeak lactic acid (mmol/l) ± SD	5.4 ± 2.6	7.4 ± 4.1	0.001
Mean lactic acid (mmol/l) ± SD	3.1 ± 3.2	5.7 ± 4.4	0.001
^dTransient lactic acidosis (%)	15 (23.8%)	48 (76.2%)	0.043
^bPeak PCO2 (mmHg)) ± SD	41.3 ± 3.5	40.4 ± 4.5	0.235
^eLowest HCO3 (mmol/l) ± SD	20.1 ± 1.8	18.9 ± 2.8	0.008

^aThe mean post-operative fasting blood glucose
^bThe mean of the highest reading in the peri-operative period ± standard deviation
^cElevation of serum creatinine > 50% of baseline measurement
^dThe patients with transient post-operative lactic acid > 5 U/l and bicarbonate < 22 mmol/l
^eThe mean of the lowest reading in the peri-operative period ± standard deviation

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