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Table 2 Vital signs and laboratory results at baseline and after follow-up

From: Efficacy and safety of enzyme-replacement-therapy with agalsidase alfa in 36 treatment-naïve Fabry disease patients

 

Baseline

After follow up

Frequency

Mean

±

SD

Mean

±

SD

 

Vital signs (n = 36)

 Systolic BP (mmHg)

123.0

±

14.9

125.9

±

14.4

every 2 weeks

 Diastolic BP (mmHg)

65.4

±

10.9

67.8

±

11.2

every 2 weeks

 Pulse (/min)

69.1

±

15.3

68.7

±

13.0

every 2 weeks

Hematological test (n = 36)

 WBC (102/mL)

59.7

±

18.2

60.2

±

15.0

once a month

 RBC (104/mL)

445.0

±

34.2

446.5

±

40.4

once a month

 Hg (g/dL)

13.2

±

1.2

13.1

±

1.5

once a month

 Ht (%)

39.6

±

3.2

39.2

±

3.7

once a month

 Plt (104/mL)

23.0

±

6.0

23.4

±

6.7

once a month

Blood chemistry test (n = 36)

 TP (g/dL)

7.1

±

0.4

7.1

±

0.4

once a month

 Alb (g/dL)

4.4

±

0.2

4.3

±

0.2

once a month

 T-Bil (mg/dL)

0.5

±

0.2

0.5

±

0.3

once a month

 ALP (U/L)

261.4

±

155.1

239.8

±

72.2

once a month

 AST (U/L)

22.9

±

10.4

24.5

±

8.2

once a month

 ALT (U/L)

18.0

±

17.8

19.7

±

12.0

once a month

 y-GTP (U/L)

29.9

±

25.5

37.2

±

29.5

once a month

 T-Cho (mg/dL)

197.3

±

39.0

198.4

±

37.7

once a month

 HDL (mg/dL)

72.7

±

14.2

74.9

±

14.2

once a month

 TG (mg/dL)

100.4

±

65.4

108.5

±

48.7

once a month

 LDL (mg/dL)

111.4

±

31.6

116.0

±

31.5

once a month

 LDH (U/L)

208.8

±

53.0

233.0

±

67.6

once a month

 CK (U/L)

103.4

±

49.0

107.9

±

50.3

once a month

 BUN (mg/dL)

12.3

±

3.6

14.8

±

12.3

once a month

 UA (mg/dL)

4.7

±

1.3

4.8

±

0.9

once a month

 Cre (mg/dL)

0.71

±

0.13

0.92

±

1.19

once a month

 eGFR (mL/min/1.73 m2)

83.5

±

28.6

82.6

±

29.4

once a month

 Na (mEq/L)

141.0

±

2.0

140.8

±

2.0

once a month

 Cl (mEq/L)

105.0

±

2.3

105.7

±

1.5

once a month

 K (mEq/L)

4.2

±

0.3

4.4

±

0.4

once a month

 CRP (mg/dL)

0.30

±

1.17

0.42

±

1.54

once a month

 hs-Trop I (pg/mL)

56.9

±

116.8

58.0

±

89.6

once a month

 BNP (mg/dL)

86.3

±

149.4

62.2

±

72.8

once a month

 β2-MG (mg/L)

1.37

±

0.35

1.78

±

1.98

once a month

 Cystatin C (mg/L)

0.67

±

0.11

0.94

±

0.90

once a month

 FT3 (pg/mL)

2.79

±

0.38

2.94

±

0.35

every 6 months

 FT4 (ng/dL)

1.07

±

0.14

1.00

±

0.15

every 6 months

 TSH (mg/dL)

1.64

±

0.90

1.60

±

0.82

every 6 months

Urinalysis (n = 36)

 UP/Cr ratio

0.19

±

0.27

0.39

±

0.72

once a month

 NAG (U/L)

4.5

±

3.0

3.8

±

2.4

once a month

anti-αGal Ab (n = 36)

negative (n = 36)

negative (n = 35)

every 6 or 12 months

 

positive (n = 0)

positive (n = 1)