Fig. 6
From: Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction
Diagram of different molecular vasoactive pathways involved in the regulation of hepatic hemodynamics with more than 20 drug classes. List of interactions between pathways: blue arrows - enhancing interactions; red arrows - inhibitory interactions; black arrows - interactions depending on drug class; dark blue tiles: interrelated drug classes; yellow text - drug classes with substance investigated in this study; white text - drug classes not investigated in this study. List of abbreviations: Ca2+- Calcium; cAMP - cyclic adenosine monophosphate; cGMP - cyclic guanosine monophosphate; COX 1/2 -Cyclooxygenase-1/2; DAG – Diacylglycerol; EET- Epoxyeicosatrienoic acids; ET-1-Endothelin 1; ET-RA-Endothelin receptor type A; ET-RB1/2 - Endothelin receptor type B 1/2; GTP - Guanosine triphosphate; HETE - Hydroxyeicosatetraenoic acids; HO - Haeme oxygenase; IP3 - Inositol 1,4,5-trisphosphate; K+ -Potassium; LA - Lysophosphatidic acid; NO - Nitric oxide; NOS - Nitric oxide synthetase; PA- Phosphatidic acid; PDGF - Platelet-derived growth factor; PGH2 - Prostaglandin H2; PGI2 - Prostacyclin; PGIS -Prostacyclin synthase; PIP2 - Phosphatidylinositol 4,5-bisphosphate; PKC- Protein kinase C; PLC -Phospholipase C; PLD - Phospholipase D; TXA2- thromboxane A2; TXS- Thromboxane synthase. List of references contributing to the development of the diagram: PMID:3904482; PMID:11889082; PMID:16518376; PMID:19789382; PMID:3356403; PMID:18484616; PMID:22468079; PMID:7938175; PMID:2194921; PMID:18346684; PMID:12846445; PMID:10728801; PMID:8253109