Table 2 Effect of treatment with compound 1 (11,13-diidrozaluzanin C) and 2 (Gochnatiolide C) on the cell cycle in MCF-7 cells associated or not to Doxorubicin. Mean ± standard deviation and reduction ratio of mitotic activity of tested cells

Control

77.5 ± 4.03^a

-

Doxorrubicin (D) - 0.3 μM

35.25 ± 4.5^b

2.19

Compound 1–28 μM

47.5 ± 5.25^c

1.63

Compound 1–28 μM+ D 0.3 μM

42.5 ± 7.85^b,c

1.82

Compound 2–1.0 μM

37.25 ± 3.09^b

2.08

Compound 2–1.0 μM + D 0.3 μM

28.5 ± 7.5^b

2.71