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Table 2 Effect of treatment with compound 1 (11,13-diidrozaluzanin C) and 2 (Gochnatiolide C) on the cell cycle in MCF-7 cells associated or not to Doxorubicin. Mean ± standard deviation and reduction ratio of mitotic activity of tested cells

From: Actions of sesquiterpene lactones isolated from Moquiniastrum polymorphum subsp. floccosum in MCF7 cell line and their potentiating action on doxorubicin

Concentrations Frequency of cells in mitotic activity MARR
Mean ± SD
Control 77.5 ± 4.03a -
Doxorrubicin (D) - 0.3 μM 35.25 ± 4.5b 2.19
11,13-diidrozaluzanin C (Compound 1)
Compound 1–28 μM 47.5 ± 5.25c 1.63
Compound 1–28 μM+ D 0.3 μM 42.5 ± 7.85b,c 1.82
Gochnatiolide C (Compound 2)
Compound 2–1.0 μM 37.25 ± 3.09b 2.08
Compound 2–1.0 μM + D 0.3 μM 28.5 ± 7.5b 2.71
  1. Frequency of cells in mitotic activity. Compound 1 at the concentration of 28 μM and compound 2 at the concentration of 1.0 μM combined or not with IC 50 of doxorubicin in MCF7 breast adenocarcinoma cells. SD: Standard Deviation. MARR - Mitotic Activity Reduction Ratio was obtained by calculating the ratio from the value of the control mean divided by the results obtained in the means of the tests. We analyzed 100 cells, the table represents mean and standard deviation of the mean of two independent replicates with two replicates. Different letters indicate statistically significant differences. The results were evaluated by NPAR1WAY/Wilkoxon. Significance * p <0.05