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Table 4 The frequency of culprit drug of total ADRs in two periods

From: Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China

Period 1

Period 2

Drug

No.

Drug

No.

Antibiotics

339 (53.1%)

Antibiotics

228 (21.5%)

 Cephalosporin

101

 Cephalosporin

83

 Quinolone

89

 Quinolone

65

 Macrolide

42

 Macrolide

29

 Penicillin

38

 Penicillin

21

 Lincosamide

23

 Nitroimidazole

7

 Nitroimidazole

17

 Lincosamide

6

 Aminoglycosides

7

 Glycopeptide

9

 Glycopeptide

7

 Fosfomycin

1

 Fosfomycin

6

 Antifungal

1

 Antifungal

4

 Tetracycline

1

 Antituberculotic

4

 Antituberculotic

2

 Sulfa

1

 Other

3

Chinese patent medicine

91 (14.2%)

Chinese patent medicine

171 (16.1%)

Cardiovascular

34 (5.3%)

NSAIDs

154 (14.5%)

 CCBs

5

 Conventional

139

 ACEI/ARB

5

 Cox-2 inhibitor

15

 Antilipemic

23

Cardiovascular

89 (8.4%)

 Antiarrhythmic drugs

1

 Antihypertensive

37

NSAIDs

31 (4.9%)

 Antilipemic

13

 Conventional

25

 Antiarrhythmic drugs

14

 Cox-2 inhibitor

6

 Nitrates

16

CNS drugs

17 (2.7%)

 Cardiotonic

9

 Antidepressant

7

Antithrombotic

43 (4.1%)

Improving CNS metabolism

4

CNS drugs

51 (4.8%)

 CNS muscle relaxant

2

 Antidepressant

21

 Anticonvulsant

4

 Improving CNS metabolism

2

Antiviral

16 (2.5%)

 CNS muscle relaxant

4

Gastrointestinal

15 (2.4%)

 Anticonvulsant

3

 PPI

6

 Other CNS drug

21

 Others

9

Endocrine

37 (3.5%)

Immunoregulation

11 (1.7%)

Gastrointestinal

34 (3.2%)

BAs

11 (1.7%)

 PPI

20

Cytotoxicity

7 (1.1%)

 Others

14

Respiratory

4 (0.6%)

Opioid

26 (2.5%)

Antithrombotic

4 (0.6%)

BAs

17 (1.6%)

Endocrine

3 (0.5%)

Antiviral

16 (1.5%)

Hormone

2 (0.3%)

Cytotoxicity

15 (1.4%)

Others

54 (8.5%)

Diuretic

15 (1.4%)

Hormone

15 (1.4%)

Antigout

11 (1.0%)

Respiratory

6 (0.6%)

Immunoregulation

5 (0.5%)

Others

127 (12.0%)