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Table 4 The frequency of culprit drug of total ADRs in two periods

From: Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China

Period 1 Period 2
Drug No. Drug No.
Antibiotics 339 (53.1%) Antibiotics 228 (21.5%)
 Cephalosporin 101  Cephalosporin 83
 Quinolone 89  Quinolone 65
 Macrolide 42  Macrolide 29
 Penicillin 38  Penicillin 21
 Lincosamide 23  Nitroimidazole 7
 Nitroimidazole 17  Lincosamide 6
 Aminoglycosides 7  Glycopeptide 9
 Glycopeptide 7  Fosfomycin 1
 Fosfomycin 6  Antifungal 1
 Antifungal 4  Tetracycline 1
 Antituberculotic 4  Antituberculotic 2
 Sulfa 1  Other 3
Chinese patent medicine 91 (14.2%) Chinese patent medicine 171 (16.1%)
Cardiovascular 34 (5.3%) NSAIDs 154 (14.5%)
 CCBs 5  Conventional 139
 ACEI/ARB 5  Cox-2 inhibitor 15
 Antilipemic 23 Cardiovascular 89 (8.4%)
 Antiarrhythmic drugs 1  Antihypertensive 37
NSAIDs 31 (4.9%)  Antilipemic 13
 Conventional 25  Antiarrhythmic drugs 14
 Cox-2 inhibitor 6  Nitrates 16
CNS drugs 17 (2.7%)  Cardiotonic 9
 Antidepressant 7 Antithrombotic 43 (4.1%)
Improving CNS metabolism 4 CNS drugs 51 (4.8%)
 CNS muscle relaxant 2  Antidepressant 21
 Anticonvulsant 4  Improving CNS metabolism 2
Antiviral 16 (2.5%)  CNS muscle relaxant 4
Gastrointestinal 15 (2.4%)  Anticonvulsant 3
 PPI 6  Other CNS drug 21
 Others 9 Endocrine 37 (3.5%)
Immunoregulation 11 (1.7%) Gastrointestinal 34 (3.2%)
BAs 11 (1.7%)  PPI 20
Cytotoxicity 7 (1.1%)  Others 14
Respiratory 4 (0.6%) Opioid 26 (2.5%)
Antithrombotic 4 (0.6%) BAs 17 (1.6%)
Endocrine 3 (0.5%) Antiviral 16 (1.5%)
Hormone 2 (0.3%) Cytotoxicity 15 (1.4%)
Others 54 (8.5%) Diuretic 15 (1.4%)
Hormone 15 (1.4%)
Antigout 11 (1.0%)
Respiratory 6 (0.6%)
Immunoregulation 5 (0.5%)
Others 127 (12.0%)