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Table 5 The frequency of culprit drug of serious ADRs in two periods

From: Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China

Period 1 Period 2
Drug No. Drug No.
Antibiotics 5 (20.8%) NSAIDs 107 (31.7%)
 Cephalosporin 2  Conventional 97
 Lincosamide 1  Cox-2 inhibitor 10
 Sulfa 1 Antibiotics 35 (10.4%)
 Cytotoxicity 1  Cephalosporin 13
Antilipemics 3 (12.5%)  Quinolone 18
Plasma expander 3 (12.5%)  Lincosamide 4
BAs 2 (8.3%) Cardiovascular 34 (10.1%)
CNS drugs 2 (8.3%)  Antihypertensive 22
Chinese patent medicine 1 (4.2%)  Antilipemic 5
ACEI/ARB 1 (4.2%)  Antiarrhythmic 4
Antithrombotic 1 (4.2%)  Nitrates 1
Endocrine 1 (4.2%)  Cardiotonic 2
Immunoregulation 1 (4.2%) Chinese patent medicine 27 (8.0%)
Others 4 (16.7%) Antithrombotic 22 (6.5%)
CNS drugs 18 (5.3%)
Endocrine 17 (5.0%)
PPI 11 (3.3%)
Hormone 8 (2.4%)
Others 59 (17.5%)