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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

Fig. 1

Scheme of the pharmacokinetic-pharmacodynamic (PK–PD) model. A1, mitiglinide amounts in the central compartment; A2, mitiglinide amounts in the peripheral compartment; C, mitiglinide concentration in the central compartment; C2, mitiglinide concentration in the peripheral compartment; V, central volume of the distribution of mitiglinide; V2, peripheral compartment; ke0, glucose disappearance rate constant; E, level of glucose in the plasma, E0, blood glucose maintained at a certain level in absence of the drug; Ce, plasma concentration in the effect compartment

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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