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Table 2 Population modeling parameters for mitiglinide after a single 10 mg oral dose to healthy volunteers (mean ± SD, n = 18)

From: Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

Parameter Mean ± SD Inter-individual variability (CV %)
Ka (/h) 9.57 ± 2.38 91.95
Tlag (h) 0.09 ± 0.01 70.71
V (L) 6.15 ± 0.33 17.61
CL (L/h) 0.03 ± 0.01 -
V2 (L) 104.69 ± 11.37 -
Cl2 (L/h) 9.85 ± 0.51 22.18
IC50 (μg/mL) 1.13 ± 0.08 -
E0 (mmol/L) 4.65 ± 0.09 4.35
Ke0 (/h) 7.47 ± 1.89 90.61
Gamma 1.66 ± 0.18 18.67