Table 2 Population modeling parameters for mitiglinide after a single 10 mg oral dose to healthy volunteers (mean ± SD, n = 18)
Parameter | Mean ± SD | Inter-individual variability (CV %) |
|---|---|---|
Ka (/h) | 9.57 ± 2.38 | 91.95 |
Tlag (h) | 0.09 ± 0.01 | 70.71 |
V (L) | 6.15 ± 0.33 | 17.61 |
CL (L/h) | 0.03 ± 0.01 | - |
V2 (L) | 104.69 ± 11.37 | - |
Cl2 (L/h) | 9.85 ± 0.51 | 22.18 |
IC50 (μg/mL) | 1.13 ± 0.08 | - |
E0 (mmol/L) | 4.65 ± 0.09 | 4.35 |
Ke0 (/h) | 7.47 ± 1.89 | 90.61 |
Gamma | 1.66 ± 0.18 | 18.67 |