Fig. 4
From: Sema3A drastically suppresses tumor growth in oral cancer Xenograft model of mice
Overexpression of Sema3A in SSC-9 cells drastically suppresses tumor growth in vivo by inhibiting angiogenesis. a overexpression of Sema3A in SSC-9 cells inhibits tumor growth in vivo compared with the control, left panel: tumor with LentiSema-EGFP transfection; right panel: tumor with LentiSema3A-EGFP transfection. b upper panel: tumor with LentiSema-EGFP transfection; lower panel: tumor with LentiSema3A-EGFP transfection. c Sema3A significantly decreases tumor weight compared with the control (p < 0.01). d Sema3A significantly suppresses tumor growth compared with the control (p < 0.01). e immunostaining of tumor specimen with CD31 antibody, left panel: tumor with LentiSema-EGFP transfection; right panel: tumor with LentiSema3A-EGFP transfection. f Sema3A significantly decreases capillary density of tumor, bar = 100 μm, p < 0.01