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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Rosiglitazone increases endothelial cell migration and vascular permeability through Akt phosphorylation

Fig. 7

siRNA against Akt-1 inhibits rosiglitazone-induced cell migration. a HUVECs transfected with Akt-1 specific siRNA or nonspecific siRNA (control) were treated with rosiglitazone (10 μM) and cell migration was assessed by a wound healing assay. Representative micrographs at × 400 magnifications (a) and the distance moved of cells (b) (n = 4, * p < 0.01 compared with control, † p < 0.01 compared with control treated with rosiglitazone, p = NS, between Akt siRNA treated groups). c and d Immunoblot analysis for the expression of phospho-Akt, phosphor-PKC β, VEGF, JAM-A, and ZO-1 (n = 4)

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