Fig. 8

(Abstract A48). GTN-induced NO formation and cGMP accumulation in intact cells. a. NO release over time was measured in VSMC infected with C-geNOp alone or in combination with either WT or C301S/C303S ALDH2 in response to 1 μM GTN b. Representative curves showing NO release in response to cumulative increasing GTN concentrations (10 nM – 1 μM) in VSMC expressing C301S/C303S ALDH2 c. Effect of 0.2 mM daidzin on GTN-derived NO formation d. GTN-induced cGMP accumulation in non-infected and infected (WT or C301S/C303S ALDH2) porcine aortic endothelial cells