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Table 1 (Abstract A12). Change from baseline in biomarkers at Week 24 in RESPITE

From: Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Mean (SD) biomarker

Baseline

Week 24

 

n

Value at baseline

n

Change from baseline

p-value for change from baseline to Week 24

cGMP (plasma), pmol/mL

53

16.25 (11.24)

51

+2.61 (8.00)

0.0240

ADMA (plasma), μmol/mL

52

0.56 (0.13)

49

–0.02 (0.12)

0.2909

NT-proBNP, pg/mL

60

1190 (1828)

51

–347 (1235)

0.0170a

GDF-15, pg/mL

53

4633 (4525)

51

–669 (2977)

0.1150

ST-2, ng/mL

53

21.08 (15.17)

51

–2.34 (9.80)

0.0947

  1. ap-value is for the relative change from baseline in NT-proBNP
  2. Baseline = the last documented value while still receiving PDE5i
  3. ADMA, asymmetric dimethylarginine; cGMP, cyclic guanosine monophosphate; GDF-15, growth differentiation factor 15; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; ST-2, suppression of tumorigenicity 2
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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