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Table 1 (Abstract A12). Change from baseline in biomarkers at Week 24 in RESPITE

From: Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Mean (SD) biomarker Baseline Week 24
  n Value at baseline n Change from baseline p-value for change from baseline to Week 24
cGMP (plasma), pmol/mL 53 16.25 (11.24) 51 +2.61 (8.00) 0.0240
ADMA (plasma), μmol/mL 52 0.56 (0.13) 49 –0.02 (0.12) 0.2909
NT-proBNP, pg/mL 60 1190 (1828) 51 –347 (1235) 0.0170a
GDF-15, pg/mL 53 4633 (4525) 51 –669 (2977) 0.1150
ST-2, ng/mL 53 21.08 (15.17) 51 –2.34 (9.80) 0.0947
  1. ap-value is for the relative change from baseline in NT-proBNP
  2. Baseline = the last documented value while still receiving PDE5i
  3. ADMA, asymmetric dimethylarginine; cGMP, cyclic guanosine monophosphate; GDF-15, growth differentiation factor 15; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; ST-2, suppression of tumorigenicity 2