Fig. 2

Exendin-4 and L-165,041 inhibit AGE-induced IL-6 (a) and TNF-α (b) production in RMC. The inhibitory action of L-165,041 was reversed by siRNA of PPARδ. L-165,041 and exendin-4 showed synergic effect in inhibiting IL-6 and TNF-α production. L-165,041 or exendin-4 alone had no influence on IL-6 or TNF-α production in the absence of AGE. (N = 6) *P < 0.05 when compared to control. +P < 0.05 when compared to AGE group. #P < 0.05 when compared to L-165,041 or exendin-4 group