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Table 1 Primary pharmacokinetic (PK) parameters of metolazone after single-dose administration of 0.5 mg, 1 mg, and 2 mg metolazone tablets and multiple-dose administration of 0.5 mg metolazone tablets in healthy Chinese volunteers

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

  Single dose Multiple dose
PK parameter 0.5 mg(n = 10) 1 mg(n = 10) 2 mg(n = 10) 0.5 mg(n = 10)
Kel (1/h) 0.1002 ± 0.0309 0.0966 ± 0.0123 0.0969 ± 0.0181 0.0957 ± 0.0227
Cmax(ng/mL) 8.2252 ± 2.7712 13.8666 ± 4.3227 28.8775 ± 11.3863 8.1967 ± 2.0941
tmax(h) 1.63 ± 0.46 1.43 ± 0.39 2.05 ± 1.11 1.63 ± 0.41
t1/2(h) 7.47 ± 2.06 7.28 ± 0.93 7.42 ± 1.60 7.61 ± 1.76
AUC0-t(ng/mL/h) 49.68 ± 14.16 91.31 ± 30.39 184.84 ± 52.39 51.35 ± 15.02
AUC0-∞(ng/mL/h) 50.51 ± 14.60 92.41 ± 31.38 186.58 ± 52.50 52.26 ± 15.28
Vd (ml) 108,732 ± 21,357 120,081 ± 23,585 126,326 ± 53,382 122,125 ± 38,729
CL(ml/h) 10,645.1 ± 3021.0 11,755.6 ± 3252.2 11,630.7 ± 3726.0 11,267.2 ± 2770.6
Cavg(ng/mL) \ \ \ 1.9595 ± 0.5118
Cmin(ng/mL) \ \ \ 0.3962 ± 0.2258
AUCss(ng/mL/h) \ \ \ 1.9595 ± 0.5118
  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, C max Maximum plasma concentration, t max Time to maximum plasma concentration, t 1/2 Apparent plasma terminal elimination half-life, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, Cavg Average plasma concentration, C min Minimum observed concentration, AUC ss AUC of distribution at steady state