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Table 1 Primary pharmacokinetic (PK) parameters of metolazone after single-dose administration of 0.5 mg, 1 mg, and 2 mg metolazone tablets and multiple-dose administration of 0.5 mg metolazone tablets in healthy Chinese volunteers

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

 

Single dose

Multiple dose

PK parameter

0.5 mg(n = 10)

1 mg(n = 10)

2 mg(n = 10)

0.5 mg(n = 10)

Kel (1/h)

0.1002 ± 0.0309

0.0966 ± 0.0123

0.0969 ± 0.0181

0.0957 ± 0.0227

Cmax(ng/mL)

8.2252 ± 2.7712

13.8666 ± 4.3227

28.8775 ± 11.3863

8.1967 ± 2.0941

tmax(h)

1.63 ± 0.46

1.43 ± 0.39

2.05 ± 1.11

1.63 ± 0.41

t1/2(h)

7.47 ± 2.06

7.28 ± 0.93

7.42 ± 1.60

7.61 ± 1.76

AUC0-t(ng/mL/h)

49.68 ± 14.16

91.31 ± 30.39

184.84 ± 52.39

51.35 ± 15.02

AUC0-∞(ng/mL/h)

50.51 ± 14.60

92.41 ± 31.38

186.58 ± 52.50

52.26 ± 15.28

Vd (ml)

108,732 ± 21,357

120,081 ± 23,585

126,326 ± 53,382

122,125 ± 38,729

CL(ml/h)

10,645.1 ± 3021.0

11,755.6 ± 3252.2

11,630.7 ± 3726.0

11,267.2 ± 2770.6

Cavg(ng/mL)

\

\

\

1.9595 ± 0.5118

Cmin(ng/mL)

\

\

\

0.3962 ± 0.2258

AUCss(ng/mL/h)

\

\

\

1.9595 ± 0.5118

  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, C max Maximum plasma concentration, t max Time to maximum plasma concentration, t 1/2 Apparent plasma terminal elimination half-life, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, Cavg Average plasma concentration, C min Minimum observed concentration, AUC ss AUC of distribution at steady state
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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