Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

Table 2 Comparison of pharmacokinetic (PK) parameters in male and female subjects after single-dose administration of 0.5 mg tablets in healthy Chinese volunteers

PK parameter	male(n = 5)		female(n = 5)		all(n = 10)
PK parameter	Mean	SD	Mean	SD	Mean	SD
Kel(1/h)	0.0865	0.0257	0.1139	0.0319	0.1002	0.0309
t_1/2(h)	8.51	2.11	6.43	1.55	7.47	2.06
t_max(h)	1.60	0.38	1.65	0.58	1.63	0.46
C_max(ng/ml)	8.3722	3.0768	8.0782	2.7853	8.2252	2.7712
AUC_0-t(ng·h/ml)	51.06	17.02	48.29	12.53	49.68	14.16
AUC_0-∞(ng·h/ml)	52.19	17.71	48.82	12.60	50.51	14.60
Vd(ml)	120,906	15,832	96,557	20,127	108,732	21,357
CL(ml/h)	10,574.6	3879.5	10,715.6	2339.0	10,645.1	3021.0
MRT_0-t(h)	10.08	4.55	7.37	1.49	8.73	3.49
MRT_0-∞(h)	11.00	4.62	7.85	1.45	9.43	3.63

All values are mean (±SD)
Kel Rate constant for elimination, t _1/2 Apparent plasma terminal elimination half-life, t _max Time to maximum plasma concentration, C _max Maximum plasma concentration, AUC _0-t AUC from 0 h to time t, AUC _0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, MRT _0-t The average residence time of zero time to t, MRT _0-∞ The average residence time of zero time to infinite time

ISSN: 2050-6511