Skip to main content

Table 2 Comparison of pharmacokinetic (PK) parameters in male and female subjects after single-dose administration of 0.5 mg tablets in healthy Chinese volunteers

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

PK parameter male(n = 5) female(n = 5) all(n = 10)
Mean SD Mean SD Mean SD
Kel(1/h) 0.0865 0.0257 0.1139 0.0319 0.1002 0.0309
t1/2(h) 8.51 2.11 6.43 1.55 7.47 2.06
tmax(h) 1.60 0.38 1.65 0.58 1.63 0.46
Cmax(ng/ml) 8.3722 3.0768 8.0782 2.7853 8.2252 2.7712
AUC0-t(ng·h/ml) 51.06 17.02 48.29 12.53 49.68 14.16
AUC0-∞(ng·h/ml) 52.19 17.71 48.82 12.60 50.51 14.60
Vd(ml) 120,906 15,832 96,557 20,127 108,732 21,357
CL(ml/h) 10,574.6 3879.5 10,715.6 2339.0 10,645.1 3021.0
MRT0-t(h) 10.08 4.55 7.37 1.49 8.73 3.49
MRT0-∞(h) 11.00 4.62 7.85 1.45 9.43 3.63
  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, t 1/2 Apparent plasma terminal elimination half-life, t max Time to maximum plasma concentration, C max Maximum plasma concentration, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, MRT 0-t The average residence time of zero time to t, MRT 0-∞ The average residence time of zero time to infinite time