Skip to main content

Table 3 Comparison of pharmacokinetic (PK) parameters in male and female subjects after single-dose administration of 1 mg tablets in healthy Chinese volunteers

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

PK parameter

male(n = 5)

female(n = 5)

all(n = 10)

Mean

SD

Mean

SD

Mean

SD

Kel(1/h)

0.1000

0.0145

0.0932

0.0100

0.0966

0.0123

t1/2(h)

7.05

1.02

7.51

0.87

7.28

0.93

tmax(h)

1.45

0.37

1.40

0.45

1.43

0.39

Cmax(ng/ml)

11.6412

1.9780

16.0920

5.0744

13.8666

4.3227

AUC0-t(ng·h/ml)

78.99

23.89

103.63

33.57

91.31

30.39

AUC0-∞(ng·h/ml)

79.81

24.60

105.01

34.84

92.41

31.38

Vd(ml)

132,420

23,825

107,742

17,417

120,081

23,585

CL(ml/h)

13,349.6

3401.1

10,161.6

2424.7

11,755.6

3252.2

MRT0-t(h)

8.78

1.32

8.82

1.81

8.80

1.50

MRT0-∞(h)

9.23

1.60

9.39

2.11

9.31

1.77

  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, t 1/2 Apparent plasma terminal elimination half-life, t max Time to maximum plasma concentration, C max Maximum plasma concentration, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, MRT 0-t The average residence time of zero time to t, MRT 0-∞ The average residence time of zero time to infinite time