PK parameter | male(n = 5) | female(n = 5) | all(n = 10) | |||
---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | |
Kel(1/h) | 0.1000 | 0.0145 | 0.0932 | 0.0100 | 0.0966 | 0.0123 |
t1/2(h) | 7.05 | 1.02 | 7.51 | 0.87 | 7.28 | 0.93 |
tmax(h) | 1.45 | 0.37 | 1.40 | 0.45 | 1.43 | 0.39 |
Cmax(ng/ml) | 11.6412 | 1.9780 | 16.0920 | 5.0744 | 13.8666 | 4.3227 |
AUC0-t(ng·h/ml) | 78.99 | 23.89 | 103.63 | 33.57 | 91.31 | 30.39 |
AUC0-∞(ng·h/ml) | 79.81 | 24.60 | 105.01 | 34.84 | 92.41 | 31.38 |
Vd(ml) | 132,420 | 23,825 | 107,742 | 17,417 | 120,081 | 23,585 |
CL(ml/h) | 13,349.6 | 3401.1 | 10,161.6 | 2424.7 | 11,755.6 | 3252.2 |
MRT0-t(h) | 8.78 | 1.32 | 8.82 | 1.81 | 8.80 | 1.50 |
MRT0-∞(h) | 9.23 | 1.60 | 9.39 | 2.11 | 9.31 | 1.77 |