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Table 3 Comparison of pharmacokinetic (PK) parameters in male and female subjects after single-dose administration of 1 mg tablets in healthy Chinese volunteers

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

PK parameter male(n = 5) female(n = 5) all(n = 10)
Mean SD Mean SD Mean SD
Kel(1/h) 0.1000 0.0145 0.0932 0.0100 0.0966 0.0123
t1/2(h) 7.05 1.02 7.51 0.87 7.28 0.93
tmax(h) 1.45 0.37 1.40 0.45 1.43 0.39
Cmax(ng/ml) 11.6412 1.9780 16.0920 5.0744 13.8666 4.3227
AUC0-t(ng·h/ml) 78.99 23.89 103.63 33.57 91.31 30.39
AUC0-∞(ng·h/ml) 79.81 24.60 105.01 34.84 92.41 31.38
Vd(ml) 132,420 23,825 107,742 17,417 120,081 23,585
CL(ml/h) 13,349.6 3401.1 10,161.6 2424.7 11,755.6 3252.2
MRT0-t(h) 8.78 1.32 8.82 1.81 8.80 1.50
MRT0-∞(h) 9.23 1.60 9.39 2.11 9.31 1.77
  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, t 1/2 Apparent plasma terminal elimination half-life, t max Time to maximum plasma concentration, C max Maximum plasma concentration, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, MRT 0-t The average residence time of zero time to t, MRT 0-∞ The average residence time of zero time to infinite time